FORMULATION AND CHARACTERIZATION OF BISOPROLOL FAST DISSOLVING FILMS PREPARED BY SOLVENT CASTING METHOD

Objective: This study aims to develop and characterize fast-dissolving films of bisoprolol, a commonly prescribed antihypertensive agent, using the solvent casting method. The objective is to create an oral dosage form that enhances patient compliance through rapid disintegration and drug release. Methods: Bisoprolol fast-dissolving films were formulated using various film-forming polymers and solvents. The solvent casting method was employed to prepare the films, with different polymer ratios and solvent compositions tested to optimize the formulation. The films were characterized for their physical appearance, thickness, tensile strength, and dissolution properties. In vitro drug release studies were conducted to evaluate the disintegration time and release profile of bisoprolol from the films. Results: The films demonstrated uniformity in appearance and a consistent thickness across formulations. The tensile strength varied with polymer composition, indicating that film mechanical properties could be tailored to specific requirements. Dissolution studies revealed that the films disintegrated rapidly, with bisoprolol releasing at an accelerated rate compared to traditional tablet forms. The optimized film formulation achieved a fast disintegration time of less than 30 seconds and a high drug release rate, meeting the criteria for fast-dissolving dosage forms. Conclusion: The solvent casting method successfully produced bisoprolol fast-dissolving films with desirable characteristics, including rapid disintegration and efficient drug release. This formulation offers a viable alternative to conventional oral dosage forms, potentially improving patient adherence and therapeutic outcomes. Future research will focus on long-term stability studies and further optimization to enhance the practical application of these films in clinical settings. Keywords: Bisoprolol, Fast Dissolving Filims