Formulation And Evaluation of Gastroretentive Floating Tablet of Alfuzosin Hydrochloride

Aim: To prepare and evaluate gastroretentive floating tablet of alfuzosin hydrochloride. Background: The innovative approach of floating drug delivery significantly contributes to the improvement of sustained release characteristics, thereby enhancing the bioavailability and half-life of the medication. Floating tablets of Alfuzosin have been formulated to extend the gastric residence time, which results in increased drug bioavailability, minimizes drug dumping, and reduces the frequency of dosing. This study aimed to develop and evaluate a sustained release floating tablet that incorporates alfuzosin hydrochloride as the active ingredient, utilizing hydrophilic polymers for the management of benign prostatic hyperplasia. Methodology: Alfuzosin HCl serves as the active pharmaceutical ingredient. Hydrophilic polymers, specifically HPMC K4M and HPMC K100M, are utilized in the formulation. The excipients employed include microcrystalline cellulose, polyvinylpyrrolidone, magnesium stearate, talc, and aerosil. The drug and polymers are combined in a mortar and pestle, followed by the uniform incorporation of the required excipients, leading to the preparation of tablets via the direct compression method. The drug was analyzed using UV spectrophotometry, while compatibility studies of the excipients were conducted through FTIR analysis. The resulting tablets underwent evaluation for various parameters, including weight variation, thickness, hardness, friability, drug content, swelling index, lag time, and drug release profiles. Ultimately, the most promising formulation was assessed for stability in accordance with ICH guidelines. Results: Considering all the evaluation parameters F5 was found to be the best formulations, with a sustained Release of 61% of the drug at the end of 8th hours