Development and assessment of an anti-acne hydrogel formulation containing Moringa oleifera leaf powder

Introduction: The development of effective and natural treatments for acne is a significant focus in dermatological research. This study presents the formulation and evaluation of an anti-acne hydrogel containing Moringa oleifera leaf powder, known for its potent antimicrobial and anti-inflammatory properties. The hydrogel was prepared using a carbopol-based gel matrix, incorporating varying concentrations of Moringa oleifera leaf powder to determine the optimal formulation. The physicochemical properties, including pH, viscosity, spreadability, and stability, were assessed. Antimicrobial activity against Propionibacterium acnes, a common acne-causing bacterium, was evaluated using agar well diffusion method. Methodology: The formulated hydrogel exhibited desirable pH and viscosity suitable for topical application. Stability studies indicated that the hydrogel maintained its consistency and efficacy over a period of three months under different storage conditions. Antimicrobial tests demonstrated significant inhibition zones, confirming the hydrogel's potent antibacterial activity against P. acnes. Additionally, the anti-inflammatory properties were assessed using in vitro assays, showing a marked reduction in pro-inflammatory cytokine production. Result: In conclusion, the Moringa oleifera leaf powder-based hydrogel shows promise as an effective and safe topical treatment for acne, leveraging the natural therapeutic benefits of Moringa oleifera. Future studies will focus on large-scale clinical trials to further validate these findings.