A Critical Review on Floating Drug Delivery System: Pharmacokinetics and Pharmacodynamic Aspects

Floating drug delivery systems (FDDS) are a novel way to retain drugs in the stomach for a longer amount of time, increasing their effectiveness. The medicine can be released more gradually and under control because to this extended stomach retention, which improves absorption and therapeutic effects. Magnetic drug carriers, expandable formulations, floating systems, and bioadhesive technologies are some of the FDDS that have been investigated. These techniques lessen the need for frequent dosing and minimize variations in drug concentration by assisting in the maintenance of ideal blood medication levels. But issues like food consumption, stomach motions, and the drug's stability in acidic environments can all have an impact on how well the system works. Researchers have created a variety of formulation methods to enhance FDDS performance, including hot melt extrusion, wet granulation, and direct compression. FDDS has been shown to considerably improve medication effectiveness, especially for medications that are most effective in the stomach or upper small intestine, according to evaluations based on floating lag time, swelling behavior, and drug release profiles. All things considered, FDDS has enormous promise for contemporary medication distribution, enhancing patient adherence and therapeutic results.