THE STUDY OF INTERLEUKIN-6 IN PATIENTS WITH SEVERE LOWER LIMB IN-JURY COMPLICATED BY FAT EMBOLISM SYNDROME

Abstract The article discusses the fat embolism syndrome (SSE), a complication that occurs with fractures of long tubular bones or pelvic bones. It is noted that the studies of recent years have been characterized by the study of the immunological mechanisms of the pathology in question, while the authors are increasingly paying attention to the peculiarities of cytokine production, in particular interleukin-6. A number of studies have shown that the levels of inflammatory mediators in the lungs increase with the development of fatty embolism, including IL-6 concentration, CD-11b expression, TNF- α it is noted that a number of authors believe that inflammatory changes in the lungs with fatty embolism syndrome are mediated by immunological disorders. Serum concentrations of IL-6 in patients with acute trauma were studied. An increase in the concentration of IL-6 in the blood serum was noted already on the first day of the post-traumatic period in patients with SGE. It is concluded that new ideas about the mechanisms of development of this pathology, taking into account immunopathogenesis, will provide new opportunities for using markers of early diagnosis of the syndrome to improve existing schemes for the prevention and treatment of traumatic fat embolism.