Gastro Retentive Microspheres Based Drug Delivery: Formulation and Evaluation

The objectives of the present investigation was to formulate and evaluate Ramipril Microspheres by using different polymers such as HPMC K-4M, HPMCK-15M, HPMCK-100M and Ethyl Cellulose. The shape of microspheres were characterized by optical microspheres and surface morphology evaluated by scanning electron microscopy. Other evolutionary parameters such as Entrapment efficiency, Buoyancy study, In-vitro study was studied. The buoyancy study compliances the floating behavior of microspheres. In-vitro study shows prolonged sustained release pattern of drug release. Scanning electron microscopy showed that microspheres surface was sponge like structure with porous in nature. The prepared Floating microspheres of Ramipril might be used for prolonged drug relese in GIT, for better drug action and improved patient compliance.