Pathophysiology And Treatment of Tuberculosis According to Who

The evolution between Mycobacterium tuberculosis infection and active tuberculosis is multi factorial and involves different biological scales. The synthesis of ESAT-6 or the induction of alveolar macrophage necrosis are key, but to understand it, it is necessary to consider the dynamics of endogenous and exogenous reinfection, drainage of lung parenchyma and respiratory mechanics, local fibrosis processes and blood supply. Severe immunosuppression can only explain 10% of active tuberculosis cases, while the remainder are attributable to comorbidities, a proinflammatory environment and an unknown genetic propensity. The pathogenic capacity of environmental mycobacteria is discrete linked to deficits in the innate and acquired immune response. The ability to generate biofilms and the ability of M. ulcer to generate the exotoxin mycolactone is remarkable. The recommendation of the world health organization and the renewed guideline of the Hungarian board of pulmonology include all criteria necessary to the effective prevention, diagnosis and therapy of multidrug, and extensively drug resistant tuberculosis. This incidence corresponds to the epidemiological data of western European countries.