Formulation And Development Of Bilayer Tablets Of Cimetidine And Sucralfate For Targeted Delivery

For researchers, creating floating tablets with the necessary buoyancy, lag time, and drug release behavior control at the target spot is an incredibly intriguing and difficult challenge. The goal of this study is to develop effervescent floating controlled release tablets containing Cimetidine and Sucralfate to treat peptic ulcers. Nine formulations (F1–F9) were created, which were for bi-layered tablets. Hydroxypropyl methylcellulose (HPMC) K100M, HPMC K4M, HPMC K15M and sodium bicarbonate were used as the swelling and floating agents, respectively, during the direct compression method's preparation of these tablets. To guarantee the quality of the produced tablets, qualitative tests including thickness, hardness, weight fluctuation, friability, and content consistency were carried out. Every formulation had a floating lag time that varied between 14 and 20 seconds. While the tablets made with HPMC K4M (F1 & F3) had a total floating duration of less than 7 hours, the effervescent floating tablets with HPMC K100M (F7, F8, & F9) had a total floating time of more than 12 hours. The disparity in the two polymers' compaction and flow characteristics may be the cause of this discrepancy in floating behavior. When compared to formulations F1, F3, and F4 that use HPMC K4M as swelling and floating polymer, formulations F7 and F9 with HPMC K100M show somewhat more sustained drug release qualities. This may be explained by HPMC K100M's improved compaction. The produced tablets exhibit diffusion kinetics that are non-Fickian. All in all, these effervescent bilayers with floating controlled release and plain tablets may enhance the compliance and therapeutic outcomes of Cimetidine and Sucralfate in treatment of peptic ulcers