A Green and Safe Synthesis of α-Hydroxyphosphonates Using Copper Nanoparticles Supported on Carbon Microspheres (Cu-NP/C)

Carbon microsphere-supported copper nanoparticles (Cu-NP/C) are an economical, efficient, non-toxic, and mild catalyst for synthesizing α-hydroxyphosphonates from 2-chloroquinoline-3-carbaldehyde and triethylphosphite under ultrasound irradiation in a solvent-free environment. This approach offers several significant benefits, including a simple experimental procedure, reduced reaction time, high product yield, and eco-friendly features due to the absence of toxic catalysts and solvents. Some of the synthesized compounds were characterized using IR, 1H NMR, and mass spectroscopy.