Phytochemical Profiling, Comparative Evaluation of The Non-Dependent Antidiabetic and Hepatoprotective Efficacy of Hemidesmus Indicus (Anatmool) Linn R Roots Extract and Conventional Therapies

The research investigates the therapeutic potential of Hemidesmus indicus (Anatmool) Linn R roots, focusing on their antidiabetic and hepatoprotective properties. Phytochemical profiling revealed bioactive compounds such as alkaloids, flavonoids, tannins, saponins, and phenolic compounds. Using dexamethasone-induced diabetes and liver toxicity models in male albino Wistar rats, the study evaluated the efficacy of ethanolic and aqueous extracts of H. indicus compared to standard therapies, pioglitazone and metformin. Results demonstrated significant reductions in blood glucose levels, improved lipid profiles, and hepatic and pancreatic histopathology. The ethanolic extract (400 mg/kg) showed notable efficacy, comparable to conventional treatments, with minimal side effects. These findings suggest H. indicus as a promising natural alternative for managing diabetes and liver disorders. Future studies are recommended to isolate active constituents and elucidate their mechanisms. This study emphasizes the importance of bridging traditional herbal medicine with contemporary therapeutic approaches to promote comprehensive health care solutions.