STUDY OF PLATELET ABNORMALITIES IN THYROID DISEASE

Abstract Introduction: Disorders related to thyroid function are among the most prevalent endocrine diseases. Certain platelet anomalies can be brought on by thyroid conditions. Patients suffering from hyperthyroidism and hypothyroidism experience varied outcomes. Hence the aim of present research was to study platelets abnormalities in patients with thyroid dysfunction and correlate with level of thyroid dysfunction. Material and Methods: Prospective study was conducted among 27 patients attending the Sharda Hospital having clinical and biochemical evidence of thyroid dysfunction were selected for this study and were subjected to relevant investigations including platelet counts and volume, coagulation profile, T3, T4, TSH. 20 subjects matched for age and sex were taken as controls. Results were computed using SPSS version 25.0. Results: 47 individuals comprising of 15 hyperthyroid, 12 hypothyroid and 20 normal control were studied and most of the subjects were 15-45 yrs of age and female to male ratio was 3:1. The mean platelet volume was much higher in hyperthyroid cases. Platelet factor 3 availability was increased in hyperthyroid group. Bleeding time, clotting time and prothrombin time was significantly prolonged in hypothyroid group whereas, in hyperthyroid group it was reduced. Conclusion: Thyroid hormone evaluation is crucial when dealing with unexplained platelet problems. Therefore, all patients with hypothyroidism and hyperthyroidism should have periodic screening for potential platelet abnormalities.