In Pursuit of Precision: Investing oxygen impact on breast cancer spheroids

This study focuses on the effects of oxygen levels on MDA-MB-231 breast cancer spheroids. By comparing spheroid growth in hyperoxic (18.5% O₂) and hypoxic (2% O₂) environments using advanced 3D cell culture techniques, the research highlights significant differences in cell growth, structure, and metabolism. The findings suggest that mimicking in vivo oxygen levels is crucial for more accurate disease modeling.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-09-30
DOI
https://doi.org/10.5281/zenodo.13853314
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

In Pursuit of Precision: Investing oxygen impact on breast cancer spheroids

Zenodo (CERN European Organization for Nuclear Research)
Cancer, Hypoxia, and Metabolism
article

In Pursuit of Precision: Investing oxygen impact on breast cancer spheroids

article en

Abstract

This study focuses on the effects of oxygen levels on MDA-MB-231 breast cancer spheroids. By comparing spheroid growth in hyperoxic (18.5% O₂) and hypoxic (2% O₂) environments using advanced 3D cell culture techniques, the research highlights significant differences in cell growth, structure, and metabolism. The findings suggest that mimicking in vivo oxygen levels is crucial for more accurate disease modeling.

Zenodo (CERN European Organization for Nuclear Research)
University of Southern Denmark (DK), University of Celaya (MX)
Openalex Percentile: Top 50%
Cancer, Hypoxia, and Metabolism
DOIOpen Access PDFOpenAlex
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In Pursuit of Precision: Investing oxygen impact on breast cancer spheroids · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS