Effect of proprioceptive training combined with regular aerobic exercise on motor function in patients with Parkinson’s disease

[Objective] To investigate the effects of proprioceptive training combined with regular aerobic exercise on motor symptoms, cognitive function and serum BDNF level in patients with Parkinson’s disease. [Methods] A total of 120 patients with Parkinson’s disease admitted to the Third Medical Center of Chinese PLA General Hospital from January 2023 to December 2023 were selected and divided into control group (n=60) and observation group (n=60) according to simple random method(single blind method). The control group only received routine intervention, and the observation group received proprioceptive training combined with regular aerobic exercise. Motor symptoms, cognitive function, serum BDNF level were assessed before and after intervention. [Results] The differences of TUGT time, Berg Balance Scale (BBS) score, length of movement track of pressure center and ellipse area of pressure center in observation group before and after intervention were greater than those in control group (P<0.05). After intervention, Montreal Cognitive Function Assessment Scale (MoCA) score, Mini-mental State Examination Scale (MMSE) score and difference of observation group were higher than those of control group (P<0.05). After intervention, the level and difference of BDNF in observation group were higher than those in control group (P<0.05). [Conclusion] Proprioceptive training combined with regular aerobic exercise can significantly improve motor symptoms and cognitive function in patients with Parkinson’s disease, and the mechanism may be related to the promotion of BDNF level.