Evaluating the Effectiveness and Stability of Regenerative Treatment and Orthodontic Tooth Movement in Stage IV Periodontitis: A Systematic Review and Meta-analysis

Background and aim: The present systematic review and meta-analysis aimed to evaluate the effectiveness and stability of regenerative treatment and orthodontic tooth movement in stage IV periodontitis. Material and methods: For the present systematic review and meta-analysis study, international databases such as MEDLINE (PubMed and Ovid), Web of Science, and Scopus were searched until October 2024 using keywords relevant to the study objectives. STATA/MP. v17 software was used to analyze data. Results: The present study included ten studies. The present meta-analysis showed a mean reduction of 1.10 mm in probing depth (95% CI, -1.18mm, -1.03mm; P < 0.001), an attachment gain of 1.96 mm (95% CI, -2.13mm,1.78mm; P < 0.001), and radiographic bone level of -1.44 mm ( 95% CI -1.65mm, -1.22mm; p<0.001). Conclusions: According to the one-year results of the present meta-analysis, an interdisciplinary approach can produce favorable and stable outcomes in motivated and cooperative patients with stage IV periodontitis who require orthodontic treatment.