Design, formulation and antimicrobial assessment of a traditional Iranian antiperspirant formula from Rosa damascena flowers and Myrtus communis leaves.

This study deals with the design and preparation of an antiperspirant formulation from traditional Iranian medicine containing aqueous decoctions of Rosa damascena Mill flowers and Myrtus communis L. leaves. The resulting product was evaluated for phytochemical content as well as physical, macroscopic, and rheological characteristics. Total tannin, total phenol, and total flavonoid contents were determined using standard spectrophotometric methods. The dilution method was used to reduce the concentration of antimicrobial protective components in the formulation and neutralize any residual activity. Most of the resulting formulated suspension products showed consistency in texture, a light brown appearance, and a pH value of 5.15. The total phenol content of R. damascena flower extract was determined as 219.1±3.42 mg GAE/g (mg gallic acid equivalent/gram of extract), and those of M. communis leaf extract and the final product were found to be 361.15±1.61 and 306.69 ±0.43 mg GAE/g respectively. Total flavonoid was 10.83±0.83 mg QE/g (mg quercetin equivalent/gram of extract) for R. damascena flower extract, 19.66±0.08 mg QE/g for M. Communis leaf extract, and 18.92±0.66 mg QE/g for the final product. The total tannin content of R. damascena flower extract was 137.92±1.17 mg QE/g, and those of M. communis leaf extract and the final product were 78.37±0.29 and 107.72±1.28 mg TA/g (mg tannic acid equivalent per gram of extract) respectively. The microbial threshold of the product was found to be quite perfectly within the permissible limit. Following pharmacopoeial and quality control assessments, the present formulation can be considered as a new health-therapeutic natural alternative for treating hyperhidrosis disorders.