Investigating a novel CXCR4 inhibitor in the context of osteoarthritis

Objectives: In the osteoarthritic (OA) knee joint, CXCL12 is primarily produced by synoviocytes in elevated levels. Human articular chondrocytes (hAC) represent potential recipient cells expressing the corresponding receptors CXCR4 and CXCR7. In vivo studies indicate that CXCL12 favors OA progression [for full text, please go to the a.m. URL]

Institutions

Universität Ulm (DE)
University and Rehabilitation Clinics Ulm (DE)

Publication Details

Journal: German Medical Science (German Research Foundation)
Published: 2024-10-21
DOI: https://doi.org/10.3205/24dkou106
Primary Topic: Chemokine receptors and signaling
Type: article
Field-Weighted Citation Impact: 0.00

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article

Investigating a novel CXCR4 inhibitor in the context of osteoarthritis

Oct 21, 2024

German Medical Science (German Research Foundation)

Chemokine receptors and signaling

article

Investigating a novel CXCR4 inhibitor in the context of osteoarthritis

October 21, 2024article en

Abstract

German Medical Science (German Research Foundation)

Universität Ulm (DE), University and Rehabilitation Clinics Ulm (DE)

Openalex Percentile: Top 55%

Chemokine receptors and signaling

DOI Open Access PDF OpenAlex

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