Bleeding of the Latest Generation Silicone Breast Implants Very Shortly Bleeding of the Latest Generation Silicone Breast Implants Very Shortly after Implantation

For decades it has been known that silicone breast implants bleed silicone molecules into the periprosthetic tissue and these are subsequently able to migrate to multiple organs. Data are emerging that silicone gel bleeding is associated with breast implant illness (BII). From the third-generation silicone breast implants in the nineties onwards, a Bleed Retardation Layer (BRL) was added to the silicone elastomer shell as a barrier, in order to retard bleeding of the silicone molecules into the surrounding tissue.This study aims to investigate whether silicone gel bleeding of the newest silicone breast implants can be detected early on after implantation. For that purpose specifically women with a short time of implantation were included in this study, which is unique. As part of the surgical explantation procedure, periprosthetic tissue from a series of 7 women who had breast implant removal early after implantation (range 3 weeks to 28 months) was examined for silicone deposits by conventional light microscopy and stained by Modified Oil Red O (MORO). Surprisingly, silicone deposits were found in periprosthetic tissue of all 7 cases, even in tissue removed within a month after implantation. These data demonstrate that silicone gel bleeding starts very shortly after implantation of the latest generation silicone breast implants.