Protease-Sensitive Linkers: A Versatile Tool for Bioresponsive Therapeutic and Diagnostic Applications

Protease-sensitive linkers (PSLs) are peptide sequences cleaved by specific proteases, making them valuable for diagnostics and therapy. By leveraging disease-associated protease activity, PSLs enable phase-specific drug delivery and diagnostic applications. They can regulate cytokine release, signal inflammation, or differentiate healthy from diseased tissue. PSLs offer potential for targeted therapeutic and diagnostic applications, highlighting their role as bioresponsive tools.