Estimation of Immunoglobulins in Iraqi SARS-CoV-2-Infected Mothers and Their Infants

Objectives: The study aimed to estimate the levels of specificimmunoglobulins (IgG, IgM, and IgA) in mothers and their infantsaffected by COVID-19 and to examine the impact of vaccination onantibody levels.Method: It was a case-control study conducted among Iraqi pregnantwomen who gave birth at Saint Raphael Hospital in Baghdad. A total of148 Iraqi pregnant women were included, with 122 females previouslyinfected with SARS-CoV-2 (group 1) and 26 healthy controls (group 2).Blood samples were collected from mothers before birth and fromnewborns after birth. The diagnosis of COVID-19 in patients was basedon clinical characteristics and PCR results. IgG, IgM, and IgA weredetected using the ELISA technique. Real-time PCR was used to detectSARS-CoV-2 RNA in nasopharyngeal swabs.Results: IgG was detected in both mothers and their infants, whileIgA was detected in mothers only. IgM was not detected in eithermothers or infants. The study also examined the impact of vaccinationon antibody levels.Conclusions: The study concludes that IgG and IgA were identified onlyin mothers, with IgM being undetectable in both mothers and theirinfants. The most robust immune responses were observed in motherswho had received the AstraZeneca vaccine. How to cite this article:Sayah S N, Al-azzawi R H. Estimation ofImmunoglobulins in Iraqi SARS-CoV-2-InfectedMothers and Their Infants. J Commun Dis.2024;56(4):132-138. DOI: https://doi.org/10.24321/0019.5138.202483