A Simple Strategy for Obtaining Bis-Indole Derivatives under Solvent Free Conditions

Bis-indole, a biomolecule which has acquired its own place in heterocyclic chemistry because of remarkable biological properties.These derivatives can be synthesized by the reaction of indole having carbonyl compound like aldehydes and ketones in the presence of an acid. Bis-indolyl compounds are formed when two moles indole reacts with an aldehyde or ketone resulting into a carbon-carbon single bond. This bond formation takes place between the C-3 of indole and carbonyl carbon of aldehyde or ketone.Current research deals with the path of obtaining bis-indole derivatives by reacting simple indole and aldehyde/ketone under solvent free microwave induced reactions. The obtained molecules were confirmed by their physical tests and organic spectroscopic analyses.