The role of platelet derived exosomes in regenerative medicine

Exosomes are a group of extracellular vesicles that are produced by various cells and are abundantly found in body fluids such as plasma. Due to their special structure, these small particles are able to carry and contain various compounds and establish cellular communication. Also, much attention has been paid to the ability of exosomes as new treatment option in various fields of regenerative medicine. One of the most abundant exosomes in plasma is platelet derived exosomes, which are rich in compounds found in platelet granules, such as growth factors. Since the use of platelets and platelet-rich plasma has been very effective in regenerative medicine, in recent years the use of platelet exosomes in regenerative medicine has received much attention and investigation. This review briefly examines the role of platelet exosomes in various fields of regenerative medicine, such as hair repair, wound healing, orthopedic injuries, angiogenesis, and drug delivery. The results of this study show that these microparticles have low immunogenicity, low thrombogenicity, and they are very useful and efficient in regenerative medicine.