Increasing Sepsis Bundle Utilization in the Inpatient Setting

Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to high mortality and significant healthcare costs. While early intervention through SEP-1 bundle components improves outcomes, adherence remains inconsistent due to delayed recognition, evolving criteria, and documentation challenges. Purpose: This evidence-based practice project aimed to increase sepsis bundle utilization in an inpatient setting by promoting early recognition and consistent protocol adherence. Methods: Guided by the Iowa Model of Evidence-Based Practice, a standardized sepsis order set was implemented and activated based on SIRS or sepsis criteria. Predictive analytics and timer tools within the EHR supported timely interventions. Data was tracked to assess compliance with bundle elements, including lactate measurement, antibiotic timing, and length of stay. Provider education and engagement campaigns were conducted. Results: Bundle utilization improved when sepsis was identified early, along with better documentation and awareness aligning with national SEP-1 quality measures. Conclusions: Standardizing protocols, leveraging predictive tools, and ongoing provider engagement helped improve SEP-1 adherence. Sustained improvement requires leadership support, continued training, and workflow integration.