Preclinical Open-Sided Magnetic Particle Imaging Scanner

Preclinical magnetic particle imaging (MPI) plays a crucial role in advancing biomedical research through in vivo studies and helps with the translation into clinical systems. Our previously developed open-sided MPI system was capable of electronic rotation and translation of the field-free line (FFL) in three dimensions. However, the field of view (FOV) was limited to 34 x 18 x 12 mm3 due to restrictions of the drive and receive coils. Here we introduce, a preclinical MPI system with a FOV of 100 x 50 x 25 mm3, which is suitable for tumor imaging in small mice. We present the imaging system design and 2D imaging results of the phantom obtained using the developed scanner.