Optimizing Natalizumab in MS: A Systematic Review of Dosing Strategies and Discontinuation Outcomes Across Treatment Paradigms

This PICO-based systematic review assesses natalizumab's effectiveness in MS through three key comparisons: (1) dosing interval optimization, (2) discontinuation outcomes, and (3) efficacy benchmarks against untreated disease. Outcomes focus on relapse rates and disability trajectories using trial and real-world data.

Publication Details

Journal
Open Science Framework
Published
2025-01-01
DOI
https://doi.org/10.17605/osf.io/wn5xr
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Optimizing Natalizumab in MS: A Systematic Review of Dosing Strategies and Discontinuation Outcomes Across Treatment Paradigms

Open Science Framework
Multiple Sclerosis Research Studies
article

Optimizing Natalizumab in MS: A Systematic Review of Dosing Strategies and Discontinuation Outcomes Across Treatment Paradigms

article en

Abstract

This PICO-based systematic review assesses natalizumab's effectiveness in MS through three key comparisons: (1) dosing interval optimization, (2) discontinuation outcomes, and (3) efficacy benchmarks against untreated disease. Outcomes focus on relapse rates and disability trajectories using trial and real-world data.

Open Science Framework
Openalex Percentile: Top 43%
Multiple Sclerosis Research Studies
DOIOpen Access PDFOpenAlex
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Optimizing Natalizumab in MS: A Systematic Review of Dosing Strategies and Discontinuation Outcomes Across Treatment Paradigms · Open Science Framework (2025) | TGRS Research Map | TGRS