Hot Sapiens Hypothesis: An Evolutionary Model of Thermogenic Anxiety and Human Adaptation

This project introduces and critically evaluates the Hot Sapiens Hypothesis — a novel evolutionary model proposing that a "hot, anxious, and thermogenic" phenotype was positively selected during Homo sapiens' migration into colder Eurasian environments. Integrating findings from genetics (e.g., FTO, UCP1, FKBP5), neurophysiology (e.g., the HPA axis, amygdala circuits), clinical psychiatry (e.g., anxiety and thermoregulatory dysfunction), and paleoanthropology (e.g., metabolic contrasts with Neanderthals), the project reframes anxiety as an adaptive thermogenic strategy. The primary manuscript provides a comprehensive synthesis of evidence, including contradictions (e.g., the FTO paradox), testable predictions, and proposals for future research. It aims to bridge molecular biology, mood disorders, and evolutionary theory, offering an interdisciplinary framework with potential implications for personalized psychiatry, human evolution, and climate-linked behavior. This project will serve as a hub for ongoing development of the hypothesis, including experimental protocols, genetic analyses, cross-species comparisons, and conceptual refinements.