Drug therapy for intracranial germ cell tumor

Intracranial germ cell tumor (IGCT) is an uncommon brain tumor, which is mostly found in male adolescents. The histology of IGCT can be divided into germinoma, mature teratoma, immature teratoma, teratoma with somatic-type malignancy, embryonic carcinoma, yolk sac tumor, choriocarcinoma and mixed intracranial germ cell tumor. Since classic high-dose radiotherapy can lead to a variety of long-term adverse effects including neurocognitive disorders and hormone secretion disorders, affecting the quality of life, chemotherapy with anti-tumor drugs is gradually increasing and clinicians have faced to more choices in the field of drug selection.