S3 File -

<div><p>Patients’ safety can be compromised in the transition of care between healthcare sectors. Optimal information flow across healthcare sectors and individualized medication treatment tailored to each patient is vital to prevent adverse events like drug-related problems. When medication changes are made during hospitalization, it is essential to ensure that the relevant general practitioner (GP) is included in the communication chain. This randomized controlled trial examines the effect of a Medication Coordinator who facilitates medication reviews in close collaboration with patients using <i>My Medication Plan</i>. Patients in the intervention group receive the medication review in combination with including suggested medication amendments documented in their electronic discharge letter send, which is sent to their GP. The patients randomized to the control group receive standard care by the ward staff. Seventy patients from the Endocrinology and Nephrology Unit at the Hospital Sønderjylland will be included in the intervention and control groups, respectively. The primary outcome is the proportion of potentially inappropriate medications. Secondary outcomes include patient-reported outcomes, i.e., quality of life and medication burden. Additional outcomes include the patient’s medication risk score, whether the patient is readmitted, and whether the patient has contacted the staff at the hospital unit after the hospital discharge. The framework for complex intervention is applied, because it allows flexibility and adaption in meeting patients’ needs by implementing tailored, possibly complex interventions in different healthcare settings. This project will examine a particular piece in the puzzle of the complexity of conducting a medication review and communication of suggested medication amendments to the patients, healthcare at the hospital, and the GP. Hopefully, this can contribute to a reduction in the risk of potentially inappropriate post-hospital medication usage.</p><p><b>Trial registration:</b> The study has been registered at ClinicalTrial.gov with the registration number: <a href="https://clinicaltrials.gov/study/NCT06383364" target="_blank">NCT06383364</a>. <a href="https://clinicaltrials.gov/study/NCT06383364" target="_blank">https://clinicaltrials.gov/study/NCT06383364</a>.</p></div>