Pharmacokinetic parameters of drugs evaluated for repurposing.

<p>Note: <b>Pharmacokinetic properties:</b> obtained from the DrugBank [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0307913#pone.0307913.ref022" target="_blank">22</a>], TTD [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0307913#pone.0307913.ref021" target="_blank">21</a>], and PubChem [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0307913#pone.0307913.ref028" target="_blank">28</a>]. <b>T</b><sub><b>max</b></sub><b>:</b> time to reach maximum plasma concentration. <b>*Total clearance estimated:</b> considering an average body weight of 70 kg by the following equations: Cl<sub>T</sub> = V<sub>d.</sub> k<sub>e</sub>, where k<sub>e</sub> = 0,693/t<sub>1/2</sub> (Cl<sub>T</sub> = total clearance; V<sub>d</sub> = volume of distribution; k<sub>e</sub> = elimination rate constant; t<sub>1/2</sub>: half-life).</p> <p>(DOCX)</p>