Genome Wide Association Study (GWAS) results: <i>P</i> < 1 x 10<sup>−6</sup>, minor allele frequency > 1%.

<p>A. Model 1: GWAS Performed on Primary Outcome (KDIGO Stage 2 or 3)—Controlling for age, sex, chip, and first 5 principal components. B. Model 2: GWAS Performed on Primary Outcome (KDIGO Stage 2 or 3)—Controlling for age, sex, chip, baseline serum creatinine, and first 5 principal components. C. Model 3: GWAS Performed on Primary Outcome (KDIGO Stage 2 or 3)—Controlling for age, sex, chip, baseline serum creatinine, lactate, total increase in SOFA score, comorbidities: diabetes complicated/uncomplicated, CHF, liver disease, peripheral vascular disease, COPD, and cardiac arrhythmias, and first 5 principal components. <u>Abbreviations</u>: CHF = congestive heart failure; Chr = Chromosome; COPD = chronic obstructive pulmonary disease; GWAS = genome-wide association study; KDIGO = Kidney Disease: Improving Global Outcomes; MAF = Minor Allele; OR = Odds Ratio; Pos = Position; Frequency; SOFA = Sequential Organ Failure Assessment; SE = Standard Error; SNP = single nucleotide polymorphism.</p> <p>(DOCX)</p>