PopPK model structure and parameter estimates.

<p>ALAG, absorption lag time; CL/F, apparent plasma clearance following oral administration; eGFR, estimated glomerular filtration rate; F1, nonlinear relative bioavailability; FABRY, Fabry disease status (0, no Fabry disease; 1, Fabry disease); FD, Fabry disease; FIX, parameter was fixed and not estimated; IIV, interindividual variability; Ka, absorption rate constant; popPK, population pharmacokinetics; Q/F, intercompartmental clearance; TADCO, time after dose capped at 24 hours; V<sub>2</sub>/F, volume of the central compartment after oral dosing; V<sub>3</sub>/F, volume of the peripheral compartment after oral dosing; WTCO, weight capped at and normalized to 70 kg.</p> <p>(PDF)</p>