Two sample MR experiments show effects of select cardiometabolic, cardiovascular, and psychiatric phenotypes on quantitative blood trait variation.

<p>We assessed the effects of instrumental variables for genetically influenced body mass index (BMI, 1244 SNPs) (Pulit et al., 2019) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref031" target="_blank">31</a>], waist-to-hip ratio (WHR, 621 SNPs) (Pulit et al., 2019) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref031" target="_blank">31</a>], Depression (58 SNPs) (Meng et al., 2024) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref034" target="_blank">34</a>], Type 2 Diabetes (T2D, 401 SNPs) (Vujkovic et al., 2020) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref032" target="_blank">32</a>], coronary artery disease (CAD, 208 SNPs) (Van Der Harst and Verweij, 2018) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref033" target="_blank">33</a>], serum Calcium level (225 SNPs) (Sinnott-Armstrong et al., 2021) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref035" target="_blank">35</a>], serum Vitamin D level (98 SNPs) (Sinnott-Armstrong et al., 2021) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref035" target="_blank">35</a>], Testosterone level (95 SNPs) (Sinnott-Armstrong et al., 2021) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref035" target="_blank">35</a>], and bone mineral density (BMD, 896 SNPs) (Morris et al., 2019) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.ref036" target="_blank">36</a>] for blood trait effects. Bars indicate 95% confidence intervals. Trait abbreviations can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0309608#pone.0309608.s011" target="_blank">S1 Table</a>. *p<0.05.</p> <p>(PDF)</p>