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<div><p>Microbial infections and excessive reactive oxygen species are the primary contributors to delays in wound healing with <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> as the common wound infection causing bacteria. In fact, wound management has become more challenging since most of these microbes have developed resistance against commonly used conventional antibiotics thus making it necessary to develop natural products with both antibacterial and antioxidant activities. Increasing attention has been paid to silk sericin in the last decade, with limited research focus in Africa. Therefore, this work focus on evaluating antibacterial and antioxidant capacity of sericin recovered from cocoons of domesticated (<i>Bombyx mori</i>, <i>Samia ricini</i>) and wild (<i>Gonometa postica</i>) silkworms in Kenya. Sericin recovery was achieved using high temperature-high pressure method. Results revealed significance interspecies variation in all the parameters. Total flavonoid content ranged between 270±60.1 and 603.3±44.1 mg GAE/100g with <i>S</i>. <i>ricini</i> demonstrating the highest whereas <i>G</i>. <i>postica</i> exhibited the least content. Moreover, <i>S</i>. <i>ricini</i> showed the highest total phenolic content at 780.0±67.6 mg QE/100g while <i>G</i>. <i>postica</i> had the least phenolic content at 330.6±14.6 mg QE/100g. <i>Samia ricini</i> revealed the highest radical scavenging capacity at 40.47 ± 3.76% whereas <i>B</i>. <i>mori</i> sericin extract showed the least radical scavenging ability at 24.6± 2.96%. Furthermore, <i>S</i>. <i>ricini</i> silk sericin extract demonstrated the highest inhibitory activity against <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumonia</i> which translated to 70.79 ± 11.28%, 93.86 ± 1.92%, 94.77 ± 7.07% when compared to streptomycin, chloramphenicol and oxytetracycline respectively. <i>Bombyx mori</i> and <i>Gonometa postica</i> showed the highest inhibitory activity against <i>S</i>. <i>pyogene</i> and <i>E</i>. <i>coli</i> respectively. These findings uncovered sufficient antibacterial efficacy of all three silk sericin extracts against both Gram-positive and negative bacteria, however, in depth research is still required to guarantee the aforementioned bioactivities to boost the therapeutic potential of silk sericin-based biomaterials.</p></div>