Summary results of TWAS fine-mapping in UK Biobank (FABIO input options for <i>π</i>).

<p>The table summarizes the number of discoveries for each of the six disease traits (rows) in the TWAS fine-mapping analysis of UK Biobank. A risk region with GWAS or TWAS signals (1<sup>st</sup> column) is defined as an LD block that harbors at least one genome-wide significant SNP or significant TWAS gene same as the definition we applied in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011503#pgen.1011503.t001" target="_blank">Table 1</a> of the main text. The following two columns list the number of genes discovered by applying FABIO with default prior and beta prior on <i>π</i>, respectively. The number in the bracket is the number of identified genes that are located in a risk region with GWAS or TWAS signals. We used an estimated FDR threshold of 0.05 to declare significance in the fine-mapping analysis.</p> <p>(DOCX)</p>

Publication Details

Journal
Figshare
Published
2024-12-02
DOI
https://doi.org/10.1371/journal.pgen.1011503.s001
Primary Topic
Genetic Associations and Epidemiology
Type
article
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article

Summary results of TWAS fine-mapping in UK Biobank (FABIO input options for π).

Figshare
Genetic Associations and Epidemiology
article

Summary results of TWAS fine-mapping in UK Biobank (FABIO input options for π).

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Abstract

<p>The table summarizes the number of discoveries for each of the six disease traits (rows) in the TWAS fine-mapping analysis of UK Biobank. A risk region with GWAS or TWAS signals (1<sup>st</sup> column) is defined as an LD block that harbors at least one genome-wide significant SNP or significant TWAS gene same as the definition we applied in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011503#pgen.1011503.t001" target="_blank">Table 1</a> of the main text. The following two columns list the number of genes discovered by applying FABIO with default prior and beta prior on <i>π</i>, respectively. The number in the bracket is the number of identified genes that are located in a risk region with GWAS or TWAS signals. We used an estimated FDR threshold of 0.05 to declare significance in the fine-mapping analysis.</p> <p>(DOCX)</p>

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Genetic Associations and Epidemiology
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