Interdigitation of S1 and S2 domains.

The model for SARS-CoV-2 Wuhan spike trimer from PDB 6VSB is rendered here with S1 in magenta and S2 in transparent green. Substantial interdigitation can be seen between the domains, with a large contact interface. The buried solvent-accessible surface area at the S1/S2 interface was calculated at 5154 Å<sup>2</sup>. This led us to the hypothesis that chimeras between low-similarity coronavirus spikes may frequently be unstable. (PDF)

Publication Details

Journal
Figshare
Published
2025-02-05
DOI
https://doi.org/10.1371/journal.pcbi.1012812.s003
Primary Topic
Nanomaterials and Printing Technologies
Type
article
Field-Weighted Citation Impact
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Interdigitation of S1 and S2 domains.

Figshare
Nanomaterials and Printing Technologies
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Interdigitation of S1 and S2 domains.

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Abstract

The model for SARS-CoV-2 Wuhan spike trimer from PDB 6VSB is rendered here with S1 in magenta and S2 in transparent green. Substantial interdigitation can be seen between the domains, with a large contact interface. The buried solvent-accessible surface area at the S1/S2 interface was calculated at 5154 Å<sup>2</sup>. This led us to the hypothesis that chimeras between low-similarity coronavirus spikes may frequently be unstable. (PDF)

Figshare
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Nanomaterials and Printing Technologies
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Interdigitation of S1 and S2 domains. · Figshare (2025) | TGRS Research Map | TGRS