Reduction in cortex volume and other regions of the brain relative to brain volume caused by loss of PHF6.

<p>(A) Volume of the cerebral cortex divided by the volume of the total brain in the sections surrounding the lateral ventricles is slightly reduced in <i>Phf6</i><sup><i>lox/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> vs. <i>Phf6</i><sup><i>+/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> brains. (B) Volume of the rest of the brain (i.e., minus the cortex and lateral ventricles), divided by the volume of the total brain in the sections surrounding the lateral ventricles in <i>Phf6</i><sup><i>lox/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> vs. <i>Phf6</i><sup><i>+/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> brains. LV = lateral ventricles. (C) Depth of individual cortical layers as percentage of total cortex depth in <i>Phf6</i><sup><i>lox/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> vs. <i>Phf6</i><sup><i>+/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> brains. N = 3 <i>Phf6</i><sup><i>lox/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> vs. 3 <i>Phf6</i><sup><i>+/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> mice (aged 394 to 483 days old). Circles represent individual animals (A-C). Lines between individual data points join each <i>Phf6</i><sup><i>lox/Y</i></sup><i>;Nes-cre</i><sup><i>Tg/+</i></sup> animal to its paired control (A,B). Data (C) are presented as mean ± sem. Data were analyzed by a paired t-test (A,B) or unpaired two-tailed t-test (C).</p> <p>(PDF)</p>