Table A: 3D Anatomical Landmarks (labels) (*Landmark not used for biometry extraction).

<p><b>Table B:</b> Formalised measurement definitions for label-based craniofacial biometry protocol with 3D T2w fetal MRI. <b>Table C:</b> Formulae for automated biometry calculation based on 3D labels. <b>Table D:</b> Demographics of the 10 cases selected for quantitative evaluation of the proposed biometry protocol and pipeline. <b>Table E:</b> Results of absolute (upper table) and relative (lower table) differences with observer 0 (manual label based indirect measurement), observer 2 and 3 (direct manual measurement) and automated results compared to a single expert radiologist (direct manual measurement. Green represents relative mean difference or <i><</i>10% or relative limits of agreement (+<i>/−</i> mean) of <i><</i>20%. Orange represents automated measurements with more variation than any one manual observer. <b>Table F:</b> Table of Intraclass Correlation Coefficient (ICC) results. Green is and excellent or good agreement, yellow a moderate agreement, red is poor agreement (n.b. ICC threshold criteria interpreted only if Cronbach’s Alpha is >0.70). <b>Table G:</b> Summary of included datasets for the 3rd trimester T21 and age-matched control cohorts, by GA, MRI protocol, fetal sex and ethnicity. <b>Table H:</b> Table of number of subjects (n), mean measurement, and standard deviation (SD)—stratified by healthy control and T21 groups. <b>Table I:</b> Best linefit and Standard Deviation (SD) regression equations and method, for each biometric growth chart. GA = GA. Note: all SD regression formulae have linear bestfit method. <b>Table J:</b> ANOVA results for statistically significant biometry with largest effect size in T21 cohort (ABSL, HPL, VPL, OFD, IFA, NASO) and BPD as a non-significant results. Results corrected with robust standard errors.</p> <p>(DOCX)</p>