Containing Supplementary Figures A to D.

<p>Fig A: Workflow to define prevalent T2D cases at T0, when metabolite data have been measured. Fig B: Comparison of betas and p-values with Smith et al. 2023 for the reverse MR on the first set of metabolites [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011346#pgen.1011346.ref018" target="_blank">18</a>]. Fig C: Manhattan plot of the interaction QTL analysis for the four metabolites significant and replicated in the EstBB. Fig D: Genomic regions around the most significant variants from the interaction QTL analyses, obtained from <a href="https://genome.ucsc.edu/" target="_blank">https://genome.ucsc.edu/</a>.</p> <p>(DOCX)</p>