Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (<i>r</i><sup>2</sup> > 0.6) with those in the polygenic risk score of outcome cancer type.

HRs were estimated using a Cox regression model adjusted for age, sex (if applicable), region, and the top 10 principal components. The adjusted HRs were further adjusted for the corresponding site-specific PRSs. No shared SNPs were found for stomach cancer PRS and ovarian cancer PRS, lung cancer PRS and cervical cancer PRS, and breast cancer PRS and stomach cancer PRS. The error bars represent 95% CIs and their centers represent the HRs. SNP, single-nucleotide polymorphism; PRS, polygenic risk score; HR, hazard ratio; CI, confidence interval. (DOCX)

Publication Details

Journal: Figshare
Published: 2025-02-28
DOI: https://doi.org/10.1371/journal.pmed.1004534.s033
Primary Topic: Genetic Associations and Epidemiology
Type: article
Field-Weighted Citation Impact: 0.00

Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (<i>r</i><sup>2</sup> > 0.6) with those in the polygenic risk score of outcome cancer type.

Publication Details

Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (r² > 0.6) with those in the polygenic risk score of outcome cancer type.

Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (r² > 0.6) with those in the polygenic risk score of outcome cancer type.

Abstract

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Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (<i>r</i><sup>2</sup> > 0.6) with those in the polygenic risk score of outcome cancer type.

Publication Details

Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (r2 > 0.6) with those in the polygenic risk score of outcome cancer type.

Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (r2 > 0.6) with those in the polygenic risk score of outcome cancer type.

Abstract

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (r² > 0.6) with those in the polygenic risk score of outcome cancer type.

Hazard ratios for the significant cross-cancer associations after excluding shared SNPs or SNPs in high linkage disequilibrium (r² > 0.6) with those in the polygenic risk score of outcome cancer type.