Bronchoscopic lavage-assisted treatment of Mycoplasma pneumonia in children：a Meta-analysis of randomized controlled trials

Objective To systematically evaluate the clinical efficacy of bronchoscopic lavage-assisted treatment of Mycoplasma pneumonia (MP) in children, providing references for clinical treatment. Methods China National Knowledge Infrastructure (CNKI), Wanfang, VIP, China Biology Medicine disc (CBM), PubMed, Embase and Web of Science were searched for randomized controlled trials of bronchoscopic lavage-assisted treatment of MP in children. Studies meeting inclusion criteria were evaluated according to the Cochrane Review manual, and Meta-analysis was performed using Stata 16.0 software. Results A total of 22 randomized controlled trials were included, all in Chinese, with a tolal of 1 774 children. Meta-analysis showed that bronchoscopic lavage-assisted treatment of MP in children significantly increased the effective rates ［RR=1.22, 95%CI(1.17, 1.26), P＜0.01］, and shortened the hospital stay ［WMD=-3.23, 95%CI (-3.64, -2.82), P＜0.01］, time to disappearance of rales ［WMD=-2.67, 95%CI (-3.12, -2.21), P＜0.01］, time to return to normal temperature ［WMD=-1.57, 95%CI (-1.84, -1.29), P＜0.01］, time to disappearance of cough ［WMD=-2.75, 95%CI (-3.40, -2.11), P＜0.01］. Conclusion Bronchoscopic lavage-assisted treatment of MP in children can significantly improve the clinical effective rate and the symptoms of children.