Analysis of epidermal NHEM scRNA-seq data taken from GSE151091 (related to Fig 1).

<p>(A) UMAP visualisation of the human skin melanocyte coloured by age group (top), donor ID (bottom left), plate ID (bottom right). (B) UMAP visualisation of the human skin melanocyte coloured by the clusters. (C) Dot plot showing the top 10 marker genes enriched in each cluster, with size depicting the percent cells expressing the gene and colour depicting the scaled mean expression value in each cluster (Wilcoxon–Mann–Whitney test with average log fold change >0.25 and adjusted <i>p</i>-value ≤0.05). (D) Dot plot depicting top 5 GO terms enriched in each cluster identified using cluster markers. (E) Stacked bar plot showing the distribution of different age groups in each of the identified cell states. All numerical data are listed in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002776#pbio.3002776.s011" target="_blank">S1 Data</a>.</p> <p>(DOCX)</p>