The <i>cpx-1</i> mutants exhibit hypersensitivity to aldicarb.

(<b>A</b>) The amino acid sequence of CPX-1, indicating the N-terminal domain (NTD), accessory domain (AD), central α-helix (CH), and C-terminal domain (CTD). Mutation sites of <i>ok1552</i> (green line), <i>syb3665</i> (blue stars), and <i>syb3584</i> (brown line) are labeled. (<b>B</b>) Aldicarb assay for the indicated strains (1 mM aldicarb). Six trials were conducted with 15 worms in each trial. <i>N</i> = 6 independent replicates. All the raw data associated with this figure are available in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003023#pbio.3003023.s016" target="_blank">S1 Data</a>. (PDF)