Clinical exploration of allogeneic PRP in refractory wound

[Objective] To explore the possibility of performing allogeneic platelet-rich plasma (PRP) treatment for patients who were not suitable for autologous PRP collection through case reports of two patients with refractory wounds treated with allogeneic PRP. [Methods] The ABO-compatible allogeneic whole blood was centrifuged 3 times to obtain allogeneic PRP within 6 hours of blood collection. Then the qualified allogeneic PRP was applied to 2 cases of refractory wound on the same day. [Results] The platelet concentration in allogeneic PRP was higher than 1 000×109/L, and the test results of infectious diseases, as well as the mixing of red blood cells and white blood cells, met the standard of quality control. Both patients achieved satisfactory wound healing outcomes (3 d). [Conclusions] For patients who were not suitable for autologous PRP treatment, allogeneic PRP might be a new option.