Application of therapeutic hemapheresis and the adverse reactions

Objective To discuss the application of therapeutic hemapheresis in clinical therapy and to observe the adverse reactions. Methods 126 times of therapeutic hemapheresis were performed in 121 patients by Nangel blood cell separator. Consumables and apheresis procedures were selected according to different treatment needs of patients. The clinical therapeutic efficacy laboratory indicators and adverse reactions during the treatment process were analyzed, and corresponding measures were taken. Results Among 100 patients who underwent platelet rich plasma (PRP) treatment, the success rate of collection was 98%. The average PRP platelet level achieved (981.22±3.55)×109/L, and the average concentration multiple of PRP achieved (4.01±0.52) times. All patients obtain symptomatic relief after treatment with PRP. The level of hemoglobin and red blood cell count of 6 polycythemia vera patients and the level of platelet of 10 essential thrombocythemia patients all decreased after therapeutic hemapheresis combined with hydroxycarbamide, with significant difference (P<0.05). Five patients with preoperative autologous blood donation have been through the surgery successfully. Out of the 121 patients, 10(8.26%) experienced mild adverse reaction (8.26%), 15(12.40%) showed bruising and bleeding at puncture site, and 1(0.83%) had pseudoaneurysm. Conclusion Therapeutic hemapheresis has the advantages of good curative effect, high success rate and low incidence of adverse reactions, and can be applied in PRP collection, removal of blood pathological components and preoperative autologous blood donation.