Value of prothrombotic state molecules and the serum level of complement C1q tumor necrosis factor-related protein 1 in predicting the prognosis of patients after percutaneous coronary intervention

Objective To investigate the value of prethrombotic state molecules and the serum level of complement C1q tumor necrosis factor-related protein 1 (CTRP1) in predicting the prognosis of patients after percutaneous coronary intervention (PCI). Methods A total of 86 patients who underwent PCI in our hospital from January 2018 to February 2020 were enrolled, and according to the presence or absence of major adverse cardiovascular events within 1 year after surgery, they were divided into good prognosis group with 71 patients and poor prognosis group with 15 patients. The two groups were compared in terms of the serum level of CTRP1 and the plasma levels of D-dimer (D-D), thrombus precursor protein (TpP), fibrinogen (Fbg), and von Willebrand factor (VWF) on admission. The receiver operating characteristic (ROC) curve was plotted and the area under the ROC curve (AUC) was calculated to assess the performance of the above indicators in predicting the prognosis of patients after PCI. Results Compared with the poor prognosis group, the good prognosis group had significantly lower plasma levels of D-D, TpP, Fbg, and vWF (t=2.094-5.664,P<0.05) and a significantly higher serum level of CTRP1 on admission (t=2.331,P<0.05). The ROC curve analysis showed that the combination of these indicators had the best performance in assessing the prognosis of patients, with an AUC of 0.935, a sensitivity of 93.33%, and a specificity of 78.87%. Conclusion Prethrombotic state molecules and serum CTRP1 level have a high accuracy in predicting the prognosis of patients after PCI, and these indicators can be monitored in clinical practice to improve the long-term prognosis of patients with coronary heart disease.