Mechanism of Estrogen and Estrogen Receptors in Pathologic Pain

Pathologic pain is a serious chronic disease, including inflammatory pain, neuropathic pain and cancer pain. Previous studies have proved a close correlation of estrogen and its receptors with pathologic pain, which plays an important role in its occurrence and development, therefore, it has attracted the attention of many researchers at home and abroad. Combining the relevant literature at home and abroad in recent years, this paper reviews the relevant research progress of the mechanism of estrogen and its receptors in pathologic pain, in order to provide a theoretical basis for the prevention and treatment of pathologic pain, as well as the guidance for future research.