Molecular Glue Mimics Recurrent Medulloblastoma Mutations in <em>KBTBD4</em>

Major Finding: Hotspot KBTBD4 mutations in medulloblastoma mimic the mechanism of action of UM171 in degrading the CoREST corepressor complex.Concept: UM171 and recurrent KBTBD4 mutations analogously enhance the interaction of KBTBD4 and HDAC1 to promote CoREST degradation.Impact: This paradigm of chemogenetic convergence may inform the future therapeutic development of molecular glues.

Publication Details

Journal: Cancer Discovery
Published: 2025-01-01
DOI: https://doi.org/10.1158/2159-8290.cd-rw2025-025
Primary Topic: Glioma Diagnosis and Treatment
Type: article
Field-Weighted Citation Impact: 0.00

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article

Molecular Glue Mimics Recurrent Medulloblastoma Mutations in KBTBD4

Jan 1, 2025

Cancer Discovery

Glioma Diagnosis and Treatment

article

Molecular Glue Mimics Recurrent Medulloblastoma Mutations in KBTBD4

January 1, 2025article en

Abstract

Cancer Discovery

Openalex Percentile: Top 38%

Glioma Diagnosis and Treatment

DOI Source OpenAlex

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Molecular Glue Mimics Recurrent Medulloblastoma Mutations in <em>KBTBD4</em> · Cancer Discovery (2025) | TGRS Research Map | TGRS