A Universal Approach\nfor High-Yield Synthesis of Single-Crystalline\nOrdered Macro-Microporous Metal–Organic Frameworks

Despite the excellent properties\nof single-crystalline\nordered\nmacro-microporous MOFs (SOM-MOFs) compared to conventional MOFs, their\nfurther development has been hindered by the lack of versatile and\nhigh-yielding preparation protocols. This study introduces an innovative\nuniversal fabrication method that can easily solve the two major challenges\nof precursor stabilization and crystallization modulation, enabling\nthe efficient synthesis of various SOM-MOFs with high yields. Notably,\nour approach has successfully yielded SOM-MIL-88A, a novel MOF showcasing\nexceptional stability in both water and acidic solutions, a remarkable\nachievement unprecedented in prior SOM-MOF research. SOM-MIL-88A has\ndemonstrated exponentially improved performance over conventional\nMIL-88A in adsorption, catalysis, immobilized enzymes, and composite\nbiosensing. Furthermore, our versatile protocol has been successfully\napplied to synthesize SOM-HKUST-1 and SOM-ZIF-8, resulting in significantly\nimproved yields (increase by about 10-fold and 2-fold, respectively,\ncompared to the previously reported protocol). This groundbreaking\nachievement marks a pivotal advancement in the preparation of diverse\nSOM-MOFs with tailored properties, presenting exciting prospects for\nfuture research on MOFs.