Palladium-CatalyzedEnantioselective StereodivergentDesymmetrization of Cyclic 1,4-Allyldiboronates

In the presence of a chiral palladium-based catalyst, 1,4-diboryl-2-alkenes undergo enantioselective cross-coupling that results in desymmetrization of the substrate structure. Depending on the reaction conditions and the choice of ligand, the reaction can occur with <i>cis</i> or <i>trans</i> selectivity, allowing the construction of an array of different substituted chiral carbocycles in an enantiomerically enriched fashion.