Interfacially\nSelf-Assembled Mutifunctional Protein\nThin Films for Accelerated Wound Healing

The design of mutifunctional protein films for large-area\nspatially\nordered arrays of functional components holds great promise in the\nfield of biomedical applications. Herein, interfacial electrostatic\nself-assembly was employed to construct a large-scale protein thin\nfilm by inducing electrostatic interactions between three bovine serum\nalbumin (BSA)-coated nanoclusters and cetyltrimethylammonium bromide\n(CTAB), leading to their spontaneous organization and uniform distribution\nat the oil–water interface. This protein film demonstrated\nexcellent multienzyme functions, high antibacterial activity, and\npH-responsive drug release capability. Therefore, it can accelerate\nthe wound closure process through a synergistic effect that includes\nreducing local blood glucose levels, regulating cellular oxidative\nstress, eradicating bacteria, and promoting cell proliferation.