Room Temperature\nRegioselective Debenzylative Cycloetherification\nReaction

A regio- and stereoselective debenzylative cycloetherification\n(DBCE) reaction of protected hexoses to form stereodefined hydroxylated\ntetrahydrofurans of synthetic utility has been investigated under\nvery mild room temperature reaction conditions. This study revealed\nthe potential application of the DBCE reaction of simple, abundant\nstarting materials to access stereochemically rich tetrahydrofuran\ncompounds under mild reaction conditions.